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You have reached the pages of the German Collaborative Research Center 654, Plasticity and sleep.

Basic hypotheses of the SFB:

• Sleep promotes memory consolidation to enable stable long-term regulation within different functional systems.
• Memory formation takes place in all systems that adapt to stressors on a long-term. Systems for which sleep-associated memory consolidation is especially important are the neurobehavioral, the metabolic and the immune system.
• Plastic processes underlying sleep-dependent memory consolidation in these systems are at least partly conveyed via the same mechanisms and signals.

Long-term research goals:

• It is intended to show that sleep reinforces memory consolidation for all three systems, i.e., the neurobehavioral, metabolic and immune system.
• It is intended to elucidate the plastic mechanisms underlying memory formation during sleep.
• By studying selected patient groups, it is intended to enable a direct application of the research to the clinical setting.

Last update: 13.04.2011